Evaluating the genetic component of ischemic stroke subtypes: A family history study. Family history in ischemic stroke before 70 years of age: The Sahlgrenska academy study on ischemic stroke. Genetic determinants of blood pressure regulation. J Hypertens ; Homocysteine and stroke: Evidence on a causal link from mendelian randomisation.
Lancet ; Genetic basis of atherosclerosis: Part 1: New genes and pathways. Circulation ; The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet ; A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke.
J Exp Med ; Nature ; Ann Neurol ; Brain ; Dichigans M.
Genetics of ischemic stroke. Lancet Neurol ; An angiotensin- converting enzyme gene polymorphism suggests a genetic distinction between ischemic stroke and carotid stenosis.
- Stroke genetics. - PubMed - NCBI.
- Nos amis les humains (Littérature générale) (French Edition).
- Afield the Scarecrows.
- Baal Shem Tov Deuteronomy?
Eur J Clin Invest ; J Neurol Sci ; Endothelial nitric oxide synthase exon7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Munshi A, Kaul S. Stroke genetics- focus on PDE4D gene. Int J Stroke ; Prothrombin gene GA mutation is not a risk factor ischemic stroke in a South Indian Hyderabadi population. Thrombosis Res ; Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies.noroi-jusatsu.info/wp-content/2020-03-27/2014-pirater-un-telephone.php
Stroke genetics: discovery, biology, and clinical applications | Neurodiem
Lipids Health Dis ; Analytic strategies for stroke genetics. J Stroke Cerebrovasc Dis ; The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. The gene encoding 5- Lipoxygenase activating protein confers risk of myocardial infarction and stroke. Association between the gene encoding 5 Lipoxygenase activating protein and stroke replicated in a Scottish population. Am J Hum Genet ; Sweeping review of human genome IDs stroke risk genes Feb 24, Mar 02, Feb 01, New gene responsible for stroke discovered Apr 07, Jan 20, Jul 14, Recommended for you.
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Your name. Note Your email address is used only to let the recipient know who sent the email. Your message. A stroke can be defined as a lack of blood flow to the brain resulting in a loss of brain function.
Typically a stroke is only classified as such when sensory deficit persists for greater than 24 hours. If the symptoms resolve completely within 24 hours this is referred to as a TIA or transient ischaemic attack. The sensory deficit associated with stroke can range from mild with complete resolution through to severe or fatal depending upon the region of the brain which loses blood supply.
Restoration of function can also range from complete to none, making stroke the leading cause of disability worldwide. Strokes can be divided into two broad categories depending upon the cause of the interrupted blood flow to the brain. This leads to blood accumulating in the sub-arachnoid space defined as a sub-arachnoid haemorrhage or SAH or accumulation of blood in the intra-cerebral space defined as an intra-cerebral haemorrhage or ICH. Ischaemic strokes are due to a lack of blood supply through small perforating arteries in the brain which supply localised areas of brain tissue.
Stroke Genetics Network (SiGN) Study
Interruption of this blood supply leads to small, localised regions of cellular death due to a lack of oxygen ischaemia. This lack of blood flow through small perforating arteries of the brain can have a number of causes which allows a further classification of ischaemic stroke into several distinct subtypes. The first of these subtypes is called small vessel disease SVD and is a consequence of fatty deposits building up on the blood vessel wall, eventually causing a blockage of the small perforating blood vessels and resulting ischaemia in the downstream brain tissue.
This fatty build up, known as atherosclerosis, occurs in all vessels throughout the body primarily as a consequence of a high fat diet. These deposits, or plaques, can also form in large vessels such as the carotid artery in the neck or the coronary artery supplying blood from the heart. If such a plaque ruptures the lipid core can cause blood to clot around the ruptured plaque, leading to possible blockage of the vessel.